Stem Cell Hack
According to the Stem Cell Theory of Aging the division and replacement of Stem Cells underlies the aging process, from wikipedia:
The number of stem cells in young people is very much higher than older people and this cause a better and more efficient replacement mechanism in the young contrary to the old. In other words, aging is not a matter of the increase of damage, but a matter of failure to replace it due to decreased number of stem cells. Stem cells decrease in number and tend to lose the ability to differentiate into progenies or lymphoid lineages and myeloid lineages.
An informed biohacker wouldn’t be surprised to learn that the Stem Cell division relies on mitochondrial function. Thus, C60 increases the pool of stem cells.
In the Paris study, the rats that received C60 did NOT develop cancer tumors that aging rats usually die of.
A 2014 Serbian paper discussed the anti-cancer potential of it as a reactive oxygen species (ROS) modulator:
One of the biologically most relevant features of C60 is the ability to quench various free radicals, behaving as a “free radical sponge”.
A recent European study proved C60’s ability to induce apoptosis of leukemic cells in combination with LED-mediated photodynamic cancer therapy.
A 2017 Chinese study noted that it mitigated the toxicity of chemotherapy:
Chemotherapy as a conventional cancer treatment suffers from critical systemic side effects, which is generally considered as the consequence of reactive oxygen species (ROS). Fullerenes have been widely studied for their excellent performance in radicals scavenging. In the present study, we report a solid-liquid reaction to synthesize fullerenols and their application as ROS scavengers in chemotherapy protection.
A 2014 study out of the Joint Ukrainian-German Center on Nanobiotechnology in Kyiv, Ukraine evaluated it in combination with the cancer drug Doxorubicin (Dox)
[C60] in tumor-bearing animals resulted in tumor growth inhibition, prolongation of life, metastasis inhibition, and increased number of apoptotic tumor cells… C60 fullerene demonstrated a protective effect against superoxide dismutase and glutathione peroxidase inhibition induced by Dox-dependent oxidative insult in the liver and heart.
A few Youtube videos and blogs about C60 incorrectly state that it has not to date been used in human trials. It has actually been used in two clinical studies…
A 2010 Japanese study of 23 women noted less wrinkles after about 8 weeks of use
Highly purified and organic solvent-free fullerene-C60 was dissolved… in squalane prepared from olive oil… [C60] cream enhanced the skin moisture and the anti-wrinkle formation. [C60] cream that was applied on a face twice daily was not effective at 4th week, but significantly more effective than the placebo at 8th week (p < 0.05) without severe side effects… We suggest that [C60] could be used as an active ingredient for wrinkle-care cosmetics.
A second 2011 Japanese study evaluated its effect treating acne
Oxidative stress plays a major role in acne formation, suggesting that oxygen radical scavengers are potential therapeutic agents. Fullerene is a spherical carbon molecule with strong radical sponge activity; therefore, we studied the effectiveness of fullerene gel in treating acne vulgaris… the fullerene gel may help in controlling acne vulgaris with skin care benefit. Fullerenes, spherical carbon cages with strong oxygen radical scavenging, with formulated into a gel and used to successfully treat acne vulgaris, an inflammatory disease associated oxidative stress.
This is quite different from other Nootropics in that it’s medium term biohack, don’t expect this to energize you in the morning like caffeine or Adaptogens do.
According to one diet hacker it increases hunger and desire to eat but not necessarily causes weight gain:
I eat a very disciplined diet and maintain a very disciplined weight/body fat%….and when I started C60, I initially experienced increased hunger which I had difficulty controlling…but, being able to control the increased hunger, my weight has dropped an average of >2 lbs in 2 weeks…And I weigh every morning and my weight doesn’t fluctuate much…so it was definitely noticeable…for what’s its worth).
On Longecity a large C60 survey has been answered by a statistically significant >100 biohackers who have used C60
- 75% of users agreed that they had a positive experience with C60 in olive oil. 20% had a neutral experience.
- 49% said it made them feel younger.
- 46% agreed that I have really much more overall energy during the day
- 58% agreed I would say C60 and Olive Oil solution has worked for me and has given me health benefits.
- 91% of users agreed that they would continue using the stuff.
Some other anecdotal effects attributed to C60 from around the internet
- Protects against poison oak
- Mitigates negative reactions to MSG
- Mitigation or elimination of chronic pain
- Restores hair to a more youthful state
- Improves eyesight
- Enhances libido
In 2017 Eastern European researchers collaborated on a study which identified C60 as a promising therapeutic agent for mitigating muscle fatigue and enhancing muscle endurance.
[C60] leads to reduction in the recovery time of the muscle contraction force and to increase in the time of active muscle functioning before appearance of steady fatigue effects. Therefore, it is possible that [C60] affects the prooxidant-antioxidant muscle tissue homeostasis, subsequently increasing muscle endurance.
The use of [C60], even at a low therapeutic dose… leads to a reduction in the recovery time of the muscle contraction force (after its complete exhaustion state) on the one hand, and an increase in the time of the muscle active work (endurance) until fatigue development on the other.
An American biohacker reported its effect on stamina
My limit on some exercises in previous years was about 20 reps. 30 or more is not a problem now. After about 10 days of C60 I began to exercise regularly after about 18 months hiatus.
In a Longecity poll 66% of respondents reported that it improved physical stamina (better condition, more muscle strength, faster recovery after endurance):
The Paris study notes that it powerfully protects the liver
Pathological examinations show that even at very low doses, 500 times lower than that used previously, C60-olive oil solutions effectively protects the livers against CCl4 toxicity. These results are in agreement with those reported for very low doses of water solution of hydrated C60 fullerene in other experimental models.
This makes it a great idea for anyone really concerned with keeping their liver happy and functional. And of course makes it a great boozing biohack!
A 2014 paper delved deeply into the potential orthopaedic applications for treating conditions like chronic back pain:
Taken together, C60 and derivatives have great potentials to serve as ROS scavenger and inflammation reliever for radiculopathy and low back pain treatment.
C60 and derivatives have shown successful applications in intensive biomedical research due to their unparalleled physical and chemical properties.
Several biohackers have reported that it aids in recovery from injury
SEPTEMBER 28, 2017: My shoulder was especially irritated and achey, even creeping into my neck… I found that the Carbon 60 package was waiting for me on the table. I decided that I would dose it immediately, and dispassionately, as I had read many accounts of possible placebo effect… I consider this to be an incredible recovery for an injury that usually requires 8-12 weeks for a full recovery… Just when I was ready to write off C60 as placebo, I had a four-day streak of incredible performance and feeling in my body during exercise, what feels like more rapid recoveries, and a general feeling of euphoria.
I’m similar — I’ve got some injuries, when I take C60, they go away. “Go away” meaning the pain diminishes.
A Hair Hack
Turnbuckle on Longecity reported
When I first tried C60 in 2012 I noted hair regrowth that filled in a bald spot to about 50% of the density of the rest of my hair. This faded slowly over a period of a year, and while there was some variability over the succeeding years… but are now increasing again, and the bald spot is filling in.
I can’t say for certain which is more responsible, as I did both oral and topical.
One guy reported that on C60 an eyebrow hair grew all the way down to his mouth!
a very long eyebrow hair, a hair that almost reached my mouth… these few super long eyebrow hairs seemed to turn up overnight.
You can buy raw powdered C60 and make your own super antioxidizing concoction. You might be able to save yourself some money in the long term by DYing your own C60 if you’re going to be taking the stuff for years but this inadvisable unless you’re a highly competent lay-chemist; it’s probably better to leave the formulation to the professionals. C60 should be dissolved in a centrifuge. Do you have a centrifuge? What you definitely wouldn’t want to do is buy some powdered C60 and then pick up some olive oil from the grocery store and mix them. The majority of the olive oil that you find at a grocery store is far from pure olive oil; often it’s diluted with cheaper, toxic oils that will mitigate the upsides of the C60.
As soon as you start Googling C60 you’ll find that it typifies the unregulated wild wild west nature of the supplement space online. This is why I’d urge you only buy from a vendor that provides a 3rd party certificate of analysis with a spectroscopy report. The only vendor I’m aware of that meets this high standard is C60Supply.com.
- It can be used to create super strong Nanotubes, so if you hope to be able to shoot spider webs out of your hands like Spiderman C60 has potential!
- Popular Science suggested it could be used in futuristic Robocop-esque body armour, The lattice of carbon atoms is 200 times stronger and six times lighter than steel.
- Interestingly, it’s the largest molecule observed to exhibit wave–particle duality; perhaps you’ve seen viral Youtube videos about the observer effect where atomic particles eerily change their behavior depending on if they are being observed by researchers. This certainly adds to the mystique surrounding C60.
C60 is not limited to appearing naturally on planet earth. Space.com reported:
NASA’s Spitzer Space Telescope, a space-based infrared observatory, spotted the buckyballs around the double-star system XX Ophiuchi. The light emitted by the carbon spheres is different than that seen in the gaseous form of buckyballs previously seen in space, allowing scientists to conclude that Spitzer had detected the material in its solid form, researchers said.
According to one very thorough biohacker on Longecity Stearic Acid enhances C60’s beneficial effect on our stem cells This Stem Cell Renewal and Mitochondrial Biogenesis protocol is prescribed…
- Stearic acid — 10 g (in hot chocolate or brownie)
- Liposomal glutathione — 1 g
- SAM-e — 200 mg
- Leucine — 5-10 g
- Curcumin phytosome — .5-1 g
- Threonine — 10 g
- PQQ — 20mg
- Liposomal glutathione — 1 g
- C60 — 3 mg (in Olive or MCT oil)
More about the protocol…
1. Stearic acid has little taste. Eating it raw is useless.
2. I’ve found that ten grams of food grade is sufficient. I’ve typically used 10-12.
3. I suggest you put the stearic acid into brownies. I’ve given the recipe in at least 2 updates.
4. The “purity” of stearic acid is almost meaningless, as has been previously discussed. Stearic acid you can buy retail is a triglyceride with 40-60% stearic and the balance palmitic acid. Doesn’t matter if it is technical, food or USP grades, it will still have the palmitic acid.
5. I don’t recommend more than a dozen treatments or so initially. I did a lot more than that, but I didn’t see any advantage.
6. If you don’t use C60 in a mito fusion state, you could deplete your stem cell pools rather than increase them.
7. Removing senescent cells is the other half of the coin. You can’t lower epigenetic age much without getting rid of them.
8. Avoid telomerase supplements, as telomerase allows old cells to become older before senescence. I added that in early on and then took it out when I realized it was a mistake.